Join us for a live webinar on Analytical Methods!

We hope you can join us for a webinar on Thursday, July 27 at 10 a.m. ET where members of our team will discuss advances in analytical methods that are transforming our understanding of capsid heterogeneity. The webinar is hosted by Xtalks, and we’ll be joined by a colleague from Sartorius BIA Separations. Register here:

Attendees will learn about:

  • Two-column processes producing 90 to 93 percent full capsids at drug substance compared to 94 percent for the ultracentrifugation (UC) process based on sedimentation velocity analytical ultracentrifugation (SV-AUC) analyses
  • How 84 to 87 percent of the encapsidated deoxyribonucleic acid (DNA) sequences in the drug-substances were full-length expression cassettes capable of expressing enhanced green fluorescent protein (eGFP) based on long-read next-generation sequencing (NGS)
  • The potencies of the drug substances from two-column processes being equivalent and potentially greater than the UC-purified drug substance
  • How the two-column processes can be more readily scaled to 500-L and 1000-L bioreactors than the UC process


  • Joe Balleydier, Senior Vice President of Research and Development, Advanced Medicine Partners
  • Mike Hatfield, Senior Director of Research and Development, Advanced Medicine Partners
  • Ales Strancar, Executive Managing Director, Sartorius BIA Separations